Stem Cell and Cancer Research

Original Articles

MSCs regulate PDGF and VEGF levels in inflammation and remodeling phases diabetes islet cell regeneration (in review)

Mesenchymal Stem Cell-Conditioned Medium Induced Serum Injury in Accelerating Wound Healing in Skin Excision Tissue (in review)

Induction of apoptosis by Typhonium flagelliforme tuber extract in breast cancer stem cells associated with the Hsp-70 expression in TAM (in review)

Intravenous administration is the best route of mesenchymal stem cells migration in improving liver function enzyme of acute liver failure

Tumor necrosis factor-α-activated mesenchymal stem cells accelerate wound healing through vascular endothelial growth factor regulation in rats

See original article in: https://www.univmed.org/ejurnal/index.php/medicina/article/download/635/524 ABSTRACT BACKGROUND Wounds are areas of physical or thermal damage of the epithelial layer of skin or mucosa. The wound healing process consists of hemostasis, inflammation, proliferation, and remodeling. Mesenchymal stem cells (MSCs) play a role in wound healing by suppressing potent proinflammatory molecules, such…

TNF-α-Activated MSC-CM Topical Gel Effective in Increasing PDGF LEVEL, Fibroblast Density, and Wound Healing Process Compared to Subcutaneous Injection Combination

Abstract Mesenchymal stem cells (MSCs) are multipotent stromal cells that have the capacity to regenerate tissue damage. However, they have several limitations. MSC-CM as a new approach treatment is widely used to solve the limitation of MSC in wound healing. The aim of this study was to evaluate the effectiveness…

The Role of TNF-α induced MSCs on Suppressive Inflammation by Increasing TGF-β and IL-10

See original article in: http://www.id-press.eu/mjms/article/view/oamjms.2018.404/2517 Abstract BACKGROUND: Mesenchymal stem cells (MSCs) may serve as immunoregulators by producing various antiinflammatory molecules. Under sufficient level of TNF-α, MSCs become activated and adopt immune-suppressive phenotype (MSCs type-2) by releasing various anti-inflammatory molecule including TGF-β and IL-10. However, the ability of MSC itself to…

The Role of Mesenchymal Stem Cells on Regulating PDGF and Islet Cells in Diabetes

See original article in Brawijaya University : https://jkb.ub.ac.id/index.php/jkb/article/download/2274/658 ABSTRACK Diabetes is a group of metabolic disease characterized by increased level of blood glucose as a result of defect in β Cells destruction and or insulin resistance. Clinical studies showed that transplantation of islet is sufficient cure to relief from the…

Effect of TNF-α Serial Doses Inducition on Increasing VEGF dan PDGF in Mesenchymal Stem Cells

See original articles in Unpad: http://journal.fk.unpad.ac.id/index.php/mkb/article/download/1278/pdf Abstract Mesenchymal Stem Cells (MSCs) have immunoregulation and regeneration capabilities through suppression of proinflammatory mediator release and increase of proliferative molecules, particularly the vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) TNF-α activated MSC in a certain dose has the ability to…

Mesenchymal stem cells accelerate liver regeneration in acute liver failure animal model

See original articles in bmrt : http://www.bmrat.org/index.php/BMRAT/article/view/498/995 ABSTRACT Introduction: The massive hepatic necrosis of acute liver failure (ALF) results in a sudden loss of hepatic cells. Although most hepatocyte cells of ALF are completely lost, stem cell-derived circulating cells and endogenous progenitor cells rapidly regenerate them. Mesenchymal stem cells (MSCs)…